Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (Record no. 1475)
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| 000 -LEADER | |
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| fixed length control field | 04051nam a22005775i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-319-30030-6 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210511122252.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 160419s2016 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783319300306 |
| -- | 978-3-319-30030-6 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-319-30030-6 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QA71-90 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PDE |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | COM014000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PDE |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 004 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tveito, Aslak. |
| Relator term | author. |
| Relationship | aut |
| -- | http://id.loc.gov/vocabulary/relators/aut |
| 9 (RLIN) | 7159 |
| 245 10 - TITLE STATEMENT | |
| Title | Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | by Aslak Tveito, Glenn T. Lines. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2016. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Cham : |
| Name of producer, publisher, distributor, manufacturer | Springer International Publishing : |
| -- | Imprint: Springer, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2016. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XVI, 261 p. 129 illus., 30 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Lecture Notes in Computational Science and Engineering, |
| International Standard Serial Number | 1439-7358 ; |
| Volume/sequential designation | 111 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Preface -- Background: Contents and Method -- One-dimensional calcium release -- Models of open and state blockers -- Two-dimensional calcium release -- Computing theoretical drugs in the two-dimensional case -- Generalized systems -- Calcium-induced calcium release -- Numerical release for CICR -- A prototypical model of an ion channel -- Inactivated ion channels -- A simple model of the sodium channel -- Mutations affecting the mean open time -- The burst mode -- Whole sale action potentials -- . |
| 506 0# - RESTRICTIONS ON ACCESS NOTE | |
| Terms governing access | Open Access |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Computer mathematics. |
| 9 (RLIN) | 357 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medicine. |
| 9 (RLIN) | 406 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Optical data processing. |
| 9 (RLIN) | 746 |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Computational Science and Engineering. |
| Authority record control number or standard number | https://scigraph.springernature.com/ontologies/product-market-codes/M14026 |
| 9 (RLIN) | 362 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biomedicine, general. |
| Authority record control number or standard number | https://scigraph.springernature.com/ontologies/product-market-codes/B0000X |
| 9 (RLIN) | 585 |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Computer Imaging, Vision, Pattern Recognition and Graphics. |
| Authority record control number or standard number | https://scigraph.springernature.com/ontologies/product-market-codes/I22005 |
| 9 (RLIN) | 3453 |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lines, Glenn T. |
| Relator term | author. |
| Relationship | aut |
| -- | http://id.loc.gov/vocabulary/relators/aut |
| 9 (RLIN) | 7160 |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 9 (RLIN) | 141 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783319300290 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783319300313 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783319807089 |
| 773 ## - HOST ITEM ENTRY | |
| Title | Springer Nature Open Access eBook |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Lecture Notes in Computational Science and Engineering, |
| International Standard Serial Number | 1439-7358 ; |
| Volume/sequential designation | 111 |
| 9 (RLIN) | 7161 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-3-319-30030-6">https://doi.org/10.1007/978-3-319-30030-6</a> |
| 912 ## - | |
| -- | ZDB-2-SMA |
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| -- | ZDB-2-SXMS |
| 912 ## - | |
| -- | ZDB-2-SOB |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | e-Books |
| -- | Administrator Library |
No items available.